Drug Information

Drug General Information
Drug ID
D09JQU
Former ID
DIB018949
Drug Name
BayCysLT2
Synonyms
CysLT2cpd
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541368]
Structure
Download
2D MOL
Formula
C34H39NO8
InChI
InChI=1S/C34H39NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h1-3,11-18,23,25,27H,4-10,19-22H2,(H,35,36)(H,37,38)(H,39,40)
InChIKey
GKPAULTWHHPIHX-UHFFFAOYSA-N
PubChem Compound ID
53394034
PubChem Substance ID
125333999, 137402854, 139222581, 178102817, 224031909, 230434689, 244009248, 252465187
Target and Pathway
Target(s) Leukotriene CysLT2 receptor Target Info Antagonist [531556]
Cysteinyl leukotriene receptor 1 Target Info Antagonist [531556]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 541368(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6196).
Ref 531556Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. FASEB J. 2011 Oct;25(10):3519-28.

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