Drug Information

Drug General Information
Drug ID
D09GDD
Former ID
DNAP001694
Drug Name
Regorafenib
Drug Type
Small molecular drug
Indication Metastatic colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Approved [532210], [541189]
Company
Bayer HealthCare Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C21H15ClF4N4O3
InChI
InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChIKey
FNHKPVJBJVTLMP-UHFFFAOYSA-N
CAS Number
CAS 755037-03-7
PubChem Compound ID
11167602
PubChem Substance ID
16247148, 23360295, 42222352, 75430857, 99437016, 123055398, 124757057, 124772081, 125163861, 126731249, 131480720, 135261819, 135626856, 135727382, 136367351, 136368060, 136920288, 136937804, 136967459, 137245314, 137275982, 142611634, 144115687, 152090526, 152258021, 152258178, 152344131, 160645781, 160647014, 162011543, 162037486, 163698233, 164041884, 164764796, 172087026, 172093559, 174530361, 175267155, 175427139, 178102514, 186014501, 188899566, 198992717, 223381220, 223498454, 223565986, 223680722, 223704854, 223925935, 226756197
ChEBI ID
ChEBI:68647
SuperDrug ATC ID
L01XE21
Target and Pathway
Target(s) Proto-oncogene tyrosine-protein kinase receptor ret Target Info Modulator [551871]
Vascular endothelial growth factor receptor 2 Target Info Modulator [551871]
Mast/stem cell growth factor receptor Target Info Modulator [551871]
KEGG Pathway Endocytosis
Pathways in cancer
Thyroid cancer
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancerhsa04014:Ras signaling pathway
Hematopoietic cell lineage
Melanogenesis
Acute myeloid leukemia
Central carbon metabolism in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_15:IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Signaling events regulated by Ret tyrosine kinase
Posttranslational regulation of adherens junction stability and dissassemblyhif2pathway:HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkcmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways SIDS Susceptibility Pathways
Dopaminergic NeurogenesisWP306:Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 532210Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
Ref 541189(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5891).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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