Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09FQB
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| Former ID |
DIB003894
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| Drug Name |
UR-12460
|
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| Indication | Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Terminated | [1] | ||
| Company |
Grupo Uriach
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
N1(C(=O)CNC(c2ccccc2)c2ccccc2)CCN(C(c2c(nccc2)C)C#N)CC1
|
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| CAS Number |
CAS 149691-90-7
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| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005037) | ||||
| REF 2 | Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. Br J Pharmacol. 1995 Feb;114(4):895-901. | ||||
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