Drug General Information
Drug ID	D09DIG
Former ID	DIB016004
Drug Name	Ablukast
Synonyms	Ablukast sodium; RO-23-3544
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 3	[545175]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Formula	C28H34O8
Canonical SMILES	c1(c(ccc(c1CCC)OCCCCCOc1c(cc2c(OC(C(=O)O)CC2)c1)C(=O)C)<br />C(=O)C)O
PubChem Compound ID	57109
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator	[1572591]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545175	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002358)
Ref 1572591	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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