Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09BHA
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| Former ID |
DIB009485
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| Drug Name |
LY-353433
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| Synonyms |
LY-343031; LY-343032; LY-314580 (oxalate); LY-350355 (maleate)
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| Indication | Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] | Terminated | [1] | ||
| Company |
Eli Lilly & Co Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(nn(c2c1cccc2)C(C)C)C(=O)NCCN1CCC(NC(=O)C23CC4CC(C3)C<br />C(C2)C4)CC1
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007508) | ||||
| REF 2 | LY353433, a potent, orally effective, long-acting 5-HT(4) receptor antagonist: comparison to cisapride and RS23597-190. J Pharmacol Exp Ther. 1996 Apr;277(1):97-104. | ||||
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