| Drug General Information |
| Drug ID |
D09AAZ
|
| Former ID |
DNC001161
|
| Drug Name |
PTAC
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H20N2O3
|
| Canonical SMILES |
C1CC(C2=C(C1)C=C(C=C2)OCC3=CC=CC=C3)N(C(=O)N)O
|
| InChI |
1S/C18H20N2O3/c19-18(21)20(22)17-8-4-7-14-11-15(9-10-16(14)17)23-12-13-5-2-1-3-6-13/h1-3,5-6,9-11,17,22H,4,7-8,12H2,(H2,19,21)
|
| InChIKey |
HGXVXGSOOPCMHM-UHFFFAOYSA-N
|
| CAS Number |
CAS 139148-95-1
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10262410, 14898924, 33517297, 80097552, 103391650, 103951629, 113465177, 125746372, 128059354, 134340391, 134340534, 135176036, 137828608, 141541204, 162789967, 234887082
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M3 |
Target Info |
Antagonist |
[1]
|
|---|
| Muscarinic acetylcholine receptor M4 |
Target Info |
Agonist |
[2]
|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
|
Insulin secretion
|
|
Salivary secretion
|
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Gastric acid secretion
|
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Pancreatic secretionhsa04080:Neuroactive ligand-receptor interaction
|
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
|
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PI3K-Akt signaling pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
PathWhiz Pathway
|
Gastric Acid ProductionPW000564:Muscle/Heart Contraction
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
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Acetylcholine regulates insulin secretion
|
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (i) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
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Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Integration of energy metabolism
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GPCR ligand binding
|
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GPCR downstream signaling
|
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GPCRs, OtherWP58:Monoamine GPCRs
|
|
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
|
GPCRs, Other
|
| References |
| REF 1 | Which muscarinic receptor is important in the bladder? World J Urol. 2001 Nov;19(5):299-306. |
|---|
| REF 2 | Function of pulmonary neuronal M(2) muscarinic receptors in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 May;163(6):1320-5. |
|---|
