Drug General Information
Drug ID	D08ZCW
Former ID	DNC001537
Drug Name	ZD-8321
Indication	Acute lung injury [ICD9: 518; ICD10:J80]		Discontinued in Phase 2	[546286]
Structure		Download 2D MOL 3D MOL
CAS Number	CAS 155944-23-3
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[535494]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 546286	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007250)
Ref 535494	Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

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