TTD | Drug: D08XNH

Drug General Information
Drug ID	D08XNH
Former ID	DCL000373
Drug Name	GSK221149
Drug Type	Small molecular drug
Indication	Threatened pre-term labour [ICD10:O60.1, P07.3]		Phase 3	[548262]
Company	GSK
Structure		Download 2D MOL 3D MOL
Formula	C11H13NO8
Canonical SMILES	C1=CC(=CC=C1[N+](=O)[O-])OC2C(C(C(C(O2)O)O)O)O
InChI	1S/C11H13NO8/c13-7-8(14)10(16)20-11(9(7)15)19-6-3-1-5(2-4-6)12(17)18/h1-4,7-11,13-16H/t7-,8-,9+,10-,11-/m0/s1
InChIKey	VZBHOPHDDNTGCY-HHKYUTTNSA-N
PubChem Compound ID	56603697
PubChem Substance ID	134339022
Target and Pathway
Target(s)	Oxytocin receptor	Target Info	Antagonist	[550963]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Oxytocin signaling pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Oxytocin receptor mediated signaling pathway
Reactome	Vasopressin-like receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Myometrial Relaxation and Contraction Pathways
	Oxytocin signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548262	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023904)
Ref 550963	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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Drug Information