| Drug General Information |
| Drug ID |
D08XFJ
|
| Former ID |
DIB001947
|
| Drug Name |
NN-1218
|
| Indication |
Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]
|
Phase 1 |
[1]
|
|---|
| Company |
Novo Nordisk A/S
|
| Target and Pathway |
| Target(s) |
Insulin receptor |
Target Info |
Modulator |
[2]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
|
Adherens junction
|
|
Insulin signaling pathway
|
|
Ovarian steroidogenesis
|
|
Type II diabetes mellitus
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Aldosterone-regulated sodium reabsorption
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
PI3 kinase pathway
|
|
Pathway Interaction Database
|
Insulin Pathway
|
|
Signaling events mediated by PTP1B
|
|
Signaling events mediated by TCPTP
|
|
Insulin-mediated glucose transport
|
|
PathWhiz Pathway
|
Insulin Signalling
|
|
Leucine Stimulation on Insulin Signaling
|
|
Reactome
|
IRS activation
|
|
Signal attenuation
|
|
Insulin receptor signalling cascade
|
|
Insulin receptor recycling
|
|
WikiPathways
|
DNA Damage Response (only ATM dependent)
|
|
Insulin Signaling
|
|
Nanoparticle triggered autophagic cell death
|
|
AGE/RAGE pathway
|
|
Signaling by Insulin receptor
|
|
Folate Metabolism
|
|
Type II diabetes mellitus
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
|
AMPK Signaling
|
| References |
| REF 1 | ClinicalTrials.gov (NCT01121289) A Trial Investigating NN1218 in Subjects With Type 1 Diabetes. U.S. National Institutes of Health. |
|---|
| REF 2 | Ultrafast-Acting Insulins: State of the Art. J Diabetes Sci Technol. 2012 July; 6(4): 728-742. |
|---|
