Drug Information

Drug General Information
Drug ID
D08XFJ
Former ID
DIB001947
Drug Name
NN-1218
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 1 [523039]
Company
Novo Nordisk A/S
Target and Pathway
Target(s) Insulin receptor Target Info Modulator [544255]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathway
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transport
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recycling
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK Signaling
References
Ref 523039ClinicalTrials.gov (NCT01121289) A Trial Investigating NN1218 in Subjects With Type 1 Diabetes. U.S. National Institutes of Health.
Ref 544255Ultrafast-Acting Insulins: State of the Art. J Diabetes Sci Technol. 2012 July; 6(4): 728-742.

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