| Drug General Information |
| Drug ID |
D08WQJ
|
| Former ID |
DNC007634
|
| Drug Name |
(3-nitro-1H-pyrazol-1-yl)(phenyl)methanone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H7N3O3
|
| Canonical SMILES |
C1=CC=C(C=C1)C(=O)N2C=CC(=N2)[N+](=O)[O-]
|
| InChI |
1S/C10H7N3O3/c14-10(8-4-2-1-3-5-8)12-7-6-9(11-12)13(15)16/h1-7H
|
| InChIKey |
MIWUBRDWBKJULS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Leukocyte elastase |
Target Info |
Inhibitor |
[1]
|
|---|
| Plasma kallikrein |
Target Info |
Inhibitor |
[1]
|
| Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Transcriptional misregulation in cancer
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Systemic lupus erythematosushsa04610:Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
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Regulation of actin cytoskeleton
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NetPath Pathway
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AndrogenReceptor Signaling PathwayNetPath_11:TCR Signaling Pathway
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PANTHER Pathway
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Blood coagulationP00011:Blood coagulation
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Pathway Interaction Database
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Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
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C-MYB transcription factor networkthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
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Angiopoietin receptor Tie2-mediated signaling
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FOXA2 and FOXA3 transcription factor networks
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PAR4-mediated thrombin signaling events
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
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PathWhiz Pathway
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CoagulationPW000047:Vitamin K Metabolism
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Coagulation
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Reactome
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Collagen degradation
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Degradation of the extracellular matrix
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Activation of Matrix MetalloproteinasesR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
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Common Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
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Thrombin signalling through proteinase activated receptors (PARs)
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WikiPathways
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
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Human Complement System
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Degradation of collagenWP558:Complement and Coagulation Cascades
|
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Blood Clotting Cascade
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Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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| References |
| REF 1 | J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. |
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