Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08VGT
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| Former ID |
DIB000950
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| Drug Name |
BMY-30129
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| Synonyms |
BMS-181162; 4-(3-Carboxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2(Z),4(E),6(E),8(E)-nonatetraenoicacid
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| Indication | Pruritus [ICD9: 698; ICD10:L29] | Discontinued in Phase 2 | [1] | ||
| Structure |
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Download2D MOL |
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| Canonical SMILES |
C\\C(=C/C=C(/C(=C/C(=O)O)/C)\\c1cccc(c1)C(=O)O)\\C=C\\C<br />2=C(C)CCCC2(C)C
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| InChI |
1S/C27H32O4/c1-18(12-14-24-19(2)8-7-15-27(24,4)5)11-13-23(20(3)16-25(28)29)21-9-6-10-22(17-21)26(30)31/h6,9-14,16-17H,7-8,15H2,1-5H3,(H,28,29)(H,30,31)/b14-12+,18-11+,20-16+,23-13-
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| InChIKey |
XKKDQOHDTASHCE-KZEPKJRYSA-N
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| Target and Pathway | |||||
| Target(s) | Phospholipase A2 | Target Info | Inhibitor | [2], [3] | |
| BioCyc Pathway | Phospholipases | ||||
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Ether lipid metabolism | |||||
| Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| alpha-Linolenic acid metabolism | |||||
| Metabolic pathways | |||||
| Ras signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Pancreatic secretion | |||||
| Fat digestion and absorption | |||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
| Reactome | Acyl chain remodelling of PC | ||||
| Acyl chain remodelling of PE | |||||
| Acyl chain remodelling of PI | |||||
| WikiPathways | Glycerophospholipid biosynthesis | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005019) | ||||
| REF 2 | Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther. 1994 Nov;271(2):852-9. | ||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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