Drug Information

Drug General Information
Drug ID
D08USJ
Former ID
DAP000563
Drug Name
Neostigmine
Synonyms
Eustigmin; Eustigmine; Intrastigmina; Juvastigmin; Neostigmin; Neostigminum; Prostigmin; Prostigmine; Prozerin; Sulfonatooxymethane; Synstigmin; Syntostigmine; Vagostigmin; Vagostigmine; Neostigmine [BAN]; Neostigmine omega; M-Trimethylammoniumphenyldimethylcarbamate; Neostigmine (BAN); Prostigmin (TN); Vagostigmin (TN); [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium; [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium; [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium bromide; Ammonium, (m-hydroxyphenyl)trimethyl-, dimethylcarbamate (ester); Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-(9CI); (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate; (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate (ester); 3-Trimethylammoniumphenyl N,N-dimethylcarbamate; 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium; 3-{[(dimethylamino)carbonyl]oxy}-N,N,N-trimethylanilinium
Drug Type
Small molecular drug
Indication Myasthenia gravis [ICD9: 358; ICD10:G70.0] Approved [550269]
Therapeutic Class
Parasympathomimetics
Structure
Download
2D MOL

3D MOL
Formula
C12H19N2O2+
Canonical SMILES
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
InChI
1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
InChIKey
ALWKGYPQUAPLQC-UHFFFAOYSA-N
CAS Number
CAS 59-99-4
PubChem Compound ID
4456
PubChem Substance ID
9467, 866380, 4398035, 4635954, 7980106, 8152746, 11111527, 11111528, 11335340, 11335373, 11360579, 11360612, 11363955, 11366517, 11369079, 11373762, 11377241, 11461551, 11461584, 11466496, 11467616, 11485012, 11486251, 11489094, 11491887, 11494875, 15121488, 26756597, 29223551, 46509161, 47216650, 47291007, 47365046, 47588860, 47736334, 47736335, 47810618, 48110324, 48416319, 49698982, 49868416, 50100289, 50100290, 50103950, 50765645, 53786926, 57322279, 81044623, 85787484, 87691541
SuperDrug ATC ID
N07AA01; S01EB06
SuperDrug CAS ID
cas=000059994
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [537124], [537383]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 550269Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537124Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr;25(4):943-50.
Ref 537383Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.

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