Drug General Information
Drug ID	D08TGY
Former ID	DNC002585
Drug Name	S-(Dimethylarsenic)Cysteine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551393]
Structure		Download 2D MOL
Formula	C5H12AsNO2S
PubChem Compound ID	46936846
Target and Pathway
Target(s)	Toll-like receptor 2	Target Info	Inhibitor	[551393]
	Human cytomegalovirus protease	Target Info	Inhibitor	[551393]
	Nitric-oxide synthase, endothelial	Target Info	Inhibitor	[551393]
BioCyc Pathway	Citrulline-nitric oxide cycle
KEGG Pathway	Phagosome
	PI3K-Akt signaling pathway
	Toll-like receptor signaling pathway
	Legionellosis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Malaria
	Toxoplasmosis
	Amoebiasis
	Tuberculosis
	Hepatitis B
	Measles
	Herpes simplex infection
	Proteoglycans in cancer
	Inflammatory bowel disease (IBD)
	Rheumatoid arthritishsa00330:Arginine and proline metabolism
	Metabolic pathways
	Calcium signaling pathway
	cGMP-PKG signaling pathway
	HIF-1 signaling pathway
	Sphingolipid signaling pathway
	VEGF signaling pathway
	Platelet activation
	Estrogen signaling pathway
	Oxytocin signaling pathway
NetPath Pathway	IL4 Signaling Pathway
	TCR Signaling PathwayNetPath_8:Wnt Signaling Pathway
PANTHER Pathway	Toll receptor signaling pathwayP00005:Angiogenesis
	Endothelin signaling pathway
	Interleukin signaling pathway
	PI3 kinase pathway
	VEGF signaling pathway
Pathway Interaction Database	Endogenous TLR signalinger_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Thromboxane A2 receptor signaling
	SHP2 signaling
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
Reactome	Beta defensins
	MyD88:Mal cascade initiated on plasma membrane
	Toll Like Receptor TLR6:TLR2 Cascade
	MyD88 deficiency (TLR2/4)
	IRAK4 deficiency (TLR2/4)R-HSA-1222556:ROS production in response to bacteria
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	eNOS activation
	Nitric oxide stimulates guanylate cyclase
	VEGFR2 mediated vascular permeability
WikiPathways	Toll-like receptor signaling pathway
	IL1 and megakaryotyces in obesity
	Human Complement System
	Toll-Like Receptors Cascades
	MyD88:Mal cascade initiated on plasma membrane
	Defensins
	Regulation of toll-like receptor signaling pathwayWP554:ACE Inhibitor Pathway
	EGF/EGFR Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	JAK/STAT
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	Endothelin Pathways
	Leptin signaling pathway
	Effects of Nitric Oxide
	Metabolism of nitric oxide
	Angiogenesis
References
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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