Drug General Information
Drug ID	D08SJL
Former ID	DNC005833
Drug Name	4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol
Synonyms	4-ethynyl-2-(4-hydroxyphenyl)quinolin-6-ol
Indication	Discovery agent		Investigative	[527681]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C#CC1=CC(=C2C=CC(=O)C=C2)NC3=C1C=C(C=C3)O
InChI	1S/C17H11NO2/c1-2-11-9-17(12-3-5-13(19)6-4-12)18-16-8-7-14(20)10-15(11)16/h1,3-10,18,20H
InChIKey	ICHYWLKAVKVIFH-UHFFFAOYSA-N
Target and Pathway
Target(s)	Estrogen receptor	Target Info	Inhibitor	[527681]
	Steroid hormone receptor ERR1	Target Info	Inhibitor	[528822]
	Estrogen receptor beta	Target Info	Inhibitor	[527681]
KEGG Pathway	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Endocrine and other factor-regulated calcium reabsorption
	Proteoglycans in cancerhsa04915:Estrogen signaling pathway
NetPath Pathway	FSH Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class II
	Plasma membrane estrogen receptor signaling
	LKB1 signaling events
	Regulation of Telomerase
	ATF-2 transcription factor network
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Validated nuclear estrogen receptor alpha network
	Signaling mediated by p38-alpha and p38-beta
	FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
Reactome	Nuclear signaling by ERBB4
	Nuclear Receptor transcription pathwayR-HSA-1989781:PPARA activates gene expression
	Transcriptional activation of mitochondrial biogenesis
	Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways	Estrogen signaling pathway
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Signaling by ERBB4
	JAK/STAT
	Integrated Pancreatic Cancer Pathway
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Integrated Breast Cancer Pathway
	Nuclear ReceptorsWP391:Mitochondrial Gene Expression
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Nuclear Receptors
References
Ref 527681	Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5.ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives.
Ref 527681	Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5.ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives.
Ref 528822	Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

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