| Drug General Information |
| Drug ID |
D08RZB
|
| Former ID |
DIB019318
|
| Drug Name |
compound 2
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C17H16ClN5OS
|
| InChI |
InChI=1S/C17H16ClN5OS/c1-9-5-4-6-12(18)15(9)23-16(24)13-8-19-17(25-13)22-14-7-10(2)20-11(3)21-14/h4-8H,1-3H3,(H,23,24)(H,19,20,21,22)
|
| InChIKey |
WFRLFWGASBLYTC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16231814, 23348306, 42207809, 46513677, 77024063, 103454583, 129574854, 140208187, 180061391, 227057194, 249565816
|
| Target and Pathway |
| Target(s) |
HCK proto-oncogene, Src family tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
|---|
| Fyn tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| FGR proto-oncogene, Src family tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| BLK proto-oncogene, Src family tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| Lck tyrosine kinase |
Target Info |
Inhibitor |
[2]
|
| Proto-oncogene tyrosine-protein kinase SRC |
Target Info |
Inhibitor |
[2]
|
| Tyrosine-protein kinase JAK3 |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Sphingolipid signaling pathway
|
|
Axon guidance
|
|
Osteoclast differentiation
|
|
Focal adhesion
|
|
Adherens junction
|
|
Platelet activation
|
|
Natural killer cell mediated cytotoxicity
|
|
T cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Cholinergic synapse
|
|
Prion diseases
|
|
Pathogenic Escherichia coli infection
|
|
Measles
|
|
Viral myocarditishsa04064:NF-kappa B signaling pathway
|
|
HTLV-I infection
|
|
Primary immunodeficiencyhsa04012:ErbB signaling pathway
|
|
Rap1 signaling pathway
|
|
Chemokine signaling pathway
|
|
Endocytosis
|
|
VEGF signaling pathway
|
|
Tight junction
|
|
Gap junction
|
|
GABAergic synapse
|
|
Inflammatory mediator regulation of TRP channels
|
|
Regulation of actin cytoskeleton
|
|
GnRH signaling pathway
|
|
Estrogen signaling pathway
|
|
Prolactin signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Oxytocin signaling pathway
|
|
Bacterial invasion of epithelial cells
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Shigellosis
|
|
Tuberculosis
|
|
Hepatitis B
|
|
Viral carcinogenesis
|
|
Proteoglycans in cancerhsa04062:Chemokine signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Jak-STAT signaling pathway
|
|
Epstein-Barr virus infection
|
|
Primary immunodeficiency
|
|
NetPath Pathway
|
TSH Signaling Pathway
|
|
IL2 Signaling Pathway
|
|
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Axon guidance mediated by semaphorins
|
|
Cadherin signaling pathway
|
|
Integrin signalling pathway
|
|
Parkinson diseaseP00049:Parkinson disease
|
|
T cell activationP00005:Angiogenesis
|
|
Parkinson disease
|
|
CCKR signaling map STP00036:Interleukin signaling pathway
|
|
JAK/STAT signaling pathway
|
|
PDGF signaling pathway
|
|
Pathway Interaction Database
|
Fc-epsilon receptor I signaling in mast cells
|
|
ErbB4 signaling events
|
|
Glypican 1 network
|
|
TCR signaling in naï
|
|
Signaling events mediated by PTP1B
|
|
Ephrin A reverse signaling
|
|
Reelin signaling pathway
|
|
Regulation of p38-alpha and p38-beta
|
|
TCR signaling in naï
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
Thromboxane A2 receptor signaling
|
|
Netrin-mediated signaling events
|
|
IL2-mediated signaling events
|
|
CXCR4-mediated signaling events
|
|
Class I PI3K signaling events
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
amb2 Integrin signaling
|
|
EPHA forward signaling
|
|
E-cadherin signaling in keratinocytes
|
|
PDGFR-beta signaling pathway
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Syndecan-3-mediated signaling events
|
|
Ephrin B reverse signaling
|
|
Alpha-synuclein signaling
|
|
Signaling events mediated by focal adhesion kinasenfkappabatypicalpathway:Atypical NF-kappaB pathway
|
|
IL12-mediated signaling events
|
|
SHP2 signaling
|
|
IL2 signaling events mediated by PI3K
|
|
IL2 signaling events mediated by STAT5
|
|
Alpha-synuclein signalingendothelinpathway:Endothelins
|
|
Signaling events mediated by PRL
|
|
LPA receptor mediated events
|
|
Atypical NF-kappaB pathway
|
|
Plasma membrane estrogen receptor signaling
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
S1P3 pathway
|
|
EPHB forward signaling
|
|
Nectin adhesion pathway
|
|
CDC42 signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Arf6 signaling events
|
|
Signaling events mediated by TCPTP
|
|
FAS (CD95) signaling pathway
|
|
Alpha9 beta1 integrin signaling events
|
|
EGF receptor (ErbB1) signaling pathway
|
|
Regulation of Androgen receptor activity
|
|
E-cadherin signaling in the nascent adherens junction
|
|
Integrins in angiogenesis
|
|
ErbB1 downstream signaling
|
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
|
ErbB2/ErbB3 signaling events
|
|
Nongenotropic Androgen signaling
|
|
Internalization of ErbB1
|
|
CXCR3-mediated signaling events
|
|
Syndecan-2-mediated signaling events
|
|
Class I PI3K signaling events mediated by Akt
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
EPHA2 forward signaling
|
|
FGF signaling pathway
|
|
Alpha4 beta1 integrin signaling events
|
|
Signaling events mediated by focal adhesion kinaseil4_2pathway:IL4-mediated signaling events
|
|
CD40/CD40L signaling
|
|
PathWhiz Pathway
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Reactome
|
GPVI-mediated activation cascade
|
|
PIP3 activates AKT signaling
|
|
Regulation of KIT signaling
|
|
Cell surface interactions at the vascular wall
|
|
FCGR activation
|
|
PECAM1 interactions
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
DAP12 signaling
|
|
EPH-Ephrin signaling
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
|
Nephrin interactions
|
|
NCAM signaling for neurite out-growth
|
|
CD28 co-stimulation
|
|
CD28 dependent PI3K/Akt signaling
|
|
CD28 dependent Vav1 pathway
|
|
CTLA4 inhibitory signaling
|
|
EPHB-mediated forward signaling
|
|
EPHA-mediated growth cone collapse
|
|
EPH-ephrin mediated repulsion of cells
|
|
CRMPs in Sema3A signaling
|
|
DCC mediated attractive signaling
|
|
Netrin mediated repulsion signals
|
|
VEGFA-VEGFR2 Pathway
|
|
Dectin-2 family
|
|
CD209 (DC-SIGN) signaling
|
|
RAF/MAP kinase cascade
|
|
Platelet Adhesion to exposed collagen
|
|
Regulation of signaling by CBL
|
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-114604:GPVI-mediated activation cascade
|
|
Phosphorylation of CD3 and TCR zeta chains
|
|
Translocation of ZAP-70 to Immunological synapse
|
|
Generation of second messenger molecules
|
|
PD-1 signaling
|
|
Interleukin-2 signalingR-HSA-114604:GPVI-mediated activation cascade
|
|
Interleukin-7 signaling
|
|
G beta:gamma signalling through PI3Kgamma
|
|
Interleukin-2 signaling
|
|
Interleukin receptor SHC signaling
|
|
WikiPathways
|
TCR Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
IL-2 Signaling Pathway
|
|
Kit receptor signaling pathway
|
|
IL-3 Signaling Pathway
|
|
Ectoderm Differentiation
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Signaling by the B Cell Receptor (BCR)
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
PIP3 activates AKT signaling
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Pathogenic Escherichia coli infection
|
|
TSLP Signaling Pathway
|
|
IL-7 Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
Platelet Adhesion to exposed collagen
|
|
Netrin-1 signaling
|
|
Nephrin interactions
|
|
NCAM signaling for neurite out-growth
|
|
Integrin-mediated Cell Adhesion
|
|
GPVI-mediated activation cascade
|
|
Costimulation by the CD28 family
|
|
Cell surface interactions at the vascular wallWP61:Notch Signaling Pathway
|
|
Inflammatory Response Pathway
|
|
TCR signaling
|
|
Costimulation by the CD28 familyWP673:ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Pregnane X Receptor pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Polycystic Kidney Disease Pathway
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
AGE/RAGE pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Angiogenesis
|
|
Androgen receptor signaling pathwayWP49:IL-2 Signaling Pathway
|
|
IL-4 Signaling Pathway
|
|
Interleukin-2 signaling
|
|
Interleukin-7 signaling
|
|
IL-9 Signaling Pathway
|
|
Interleukin-3, 5 and GM-CSF signaling
|
| References |
| REF 1 | Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck). Bioorg Med Chem Lett. 2003 Nov 17;13(22):4007-10. |
|---|
| REF 2 | Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. |
|---|
