Drug Information

Drug General Information
Drug ID
D08QIP
Former ID
DAP000977
Drug Name
Pranlukast
Synonyms
Azlaire; Azlaire (TN); Pranlukast (INN); N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Drug Type
Small molecular drug
Indication Asthma; Prophylaxis [ICD9: 493; ICD10:J45] Approved [536361], [540487]
Therapeutic Class
Antiasthmatic Agents
Structure
Download
2D MOL

3D MOL
Formula
C27H23N5O4
InChI
InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
InChIKey
NBQKINXMPLXUET-UHFFFAOYSA-N
CAS Number
CAS 103177-37-3
PubChem Compound ID
4887
PubChem Substance ID
4500848, 14859100, 29223965, 50077761, 50077772, 50126316, 53786954, 77504954, 85220005, 91615698, 92308832, 92719276, 96025094, 96078242, 103188207, 103933734, 104307712, 125335358, 126620941, 126652683, 126670729, 128679004, 135072791, 135692295, 135698209, 137212400, 139795808, 144206505, 152106761, 162182220, 163032211, 164232709, 164826461, 175611959, 176484201, 177749374, 178100541, 179149492, 186010627, 196105989, 198972268, 210279434, 210281757, 223653303, 223704738, 225068984, 226395820, 250136802, 251887611, 252156957
SuperDrug ATC ID
R03DC02
SuperDrug CAS ID
cas=103177373
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Antagonist [537612]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 540487(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3634).
Ref 537612Beneficial effects of leukotriene receptor antagonists in the prevention of cedar pollinosis in a community setting. J Investig Allergol Clin Immunol. 2009;19(3):195-203.

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