Drug Information
Drug General Information | |||||
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Drug ID |
D08MNO
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Former ID |
DIB019036
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Drug Name |
butaprost (free acid form)
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Synonyms |
butaprost acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539192] | ||
Structure |
Download2D MOL |
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Formula |
C23H38O5
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InChI |
InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18-,20-,21+/m1/s1
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InChIKey |
PAYNQYXOKJDXAV-ZHIWTBQHSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Prostacyclin receptor | Target Info | Agonist | [525673] | |
Prostaglandin E2receptor, EP2 subtype | Target Info | Agonist | [525571] | ||
Prostaglandin E2 receptor EP3 subtype | Target Info | Agonist | [525673] | ||
Thromboxane A2 receptor | Target Info | Agonist | [525673] | ||
Prostaglandin E2 receptor, EP4 subtype | Target Info | Agonist | [534595] | ||
Prostaglandin D2 receptor | Target Info | Agonist | [525673] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | |||||
Platelet activationhsa04024:cAMP signaling pathway | |||||
Inflammatory mediator regulation of TRP channels | |||||
Renin secretion | |||||
Pathways in cancerhsa04020:Calcium signaling pathway | |||||
cAMP signaling pathway | |||||
Regulation of lipolysis in adipocytes | |||||
Platelet activationhsa04080:Neuroactive ligand-receptor interaction | |||||
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction | |||||
Pathway Interaction Database | Thromboxane A2 receptor signalingtxa2pathway:Thromboxane A2 receptor signaling | ||||
Reactome | Prostanoid ligand receptors | ||||
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors | |||||
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors | |||||
G alpha (q) signalling events | |||||
G alpha (12/13) signalling events | |||||
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors | |||||
G alpha (s) signalling events | |||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
GPCRs, Class A Rhodopsin-like | |||||
Small Ligand GPCRs | |||||
Endothelin Pathways | |||||
Platelet homeostasis | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation | |||||
Ovarian Infertility Genes | |||||
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Signal amplification | |||||
Vitamin D Receptor Pathway | |||||
GPCR downstream signaling | |||||
References | |||||
Ref 525571 | Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51. | ||||
Ref 525673 | The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. | ||||
Ref 534595 | Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. |
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