Drug General Information
Drug ID
D08MNO
Former ID
DIB019036
Drug Name
butaprost (free acid form)
Synonyms
butaprost acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539192]
Structure
Download
2D MOL
Formula
C23H38O5
InChI
InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18-,20-,21+/m1/s1
InChIKey
PAYNQYXOKJDXAV-ZHIWTBQHSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [525673]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [525571]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [525673]
Thromboxane A2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534595]
Prostaglandin D2 receptor Target Info Agonist [525673]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activationhsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Platelet activationhsa04080:Neuroactive ligand-receptor interaction
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Thromboxane A2 receptor signalingtxa2pathway:Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and ProstacyclinPW000451:Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
Vitamin D Receptor Pathway
GPCR downstream signaling
References
Ref 539192(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1892).
Ref 525571Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51.
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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