Drug Information
Drug General Information | |||||
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Drug ID |
D08LZI
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Former ID |
DIB006663
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Drug Name |
NS-220
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Synonyms |
R-1593; Cis-2-Methyl-5-[4-[5-methyl-2-(4-methylphenyl)oxazol-4-yl]butyl]-1,3-dioxane-2-carboxylic acid
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C21H27NO5
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InChI |
InChI=1S/C21H27NO5/c1-14-8-10-17(11-9-14)19-22-18(15(2)27-19)7-5-4-6-16-12-25-21(3,20(23)24)26-13-16/h8-11,16H,4-7,12-13H2,1-3H3,(H,23,24)/t16-,21+
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InChIKey |
IMYPSTHZBIWMNA-NBEIKUQISA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Peroxisome proliferator activated receptor alpha | Target Info | Agonist | [529786], [551871] | |
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | ||||
Reactome | RORA activates gene expression | ||||
BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||||
PPARA activates gene expression | |||||
YAP1- and WWTR1 (TAZ)-stimulated gene expression | |||||
Transcriptional activation of mitochondrial biogenesis | |||||
Activation of gene expression by SREBF (SREBP) | |||||
Transcriptional regulation of white adipocyte differentiation | |||||
Nuclear Receptor transcription pathway | |||||
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
Circadian Clock | |||||
WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
Nuclear Receptors Meta-Pathway | |||||
Estrogen Receptor Pathway | |||||
PPAR Alpha Pathway | |||||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
Transcriptional Regulation of White Adipocyte Differentiation | |||||
YAP1- and WWTR1 (TAZ)-stimulated gene expression | |||||
Activation of Gene Expression by SREBP (SREBF) | |||||
Adipogenesis | |||||
SREBF and miR33 in cholesterol and lipid homeostasis | |||||
Circadian Clock | |||||
Nuclear Receptors | |||||
References | |||||
Ref 539744 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2678). | ||||
Ref 547609 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017798) | ||||
Ref 529786 | Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6471-5. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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