Drug General Information
Drug ID
D08LVT
Former ID
DNC006202
Drug Name
4-hydroxy-N-neopentyl-N-phenylbenzenesulfonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527880]
Structure
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2D MOL

3D MOL

Formula
C17H21NO3S
Canonical SMILES
CC(C)(C)CN(C1=CC=CC=C1)S(=O)(=O)C2=CC=C(C=C2)O
InChI
1S/C17H21NO3S/c1-17(2,3)13-18(14-7-5-4-6-8-14)22(20,21)16-11-9-15(19)10-12-16/h4-12,19H,13H2,1-3H3
InChIKey
QKNCIALYEAWCOU-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Estrogen receptor Target Info Inhibitor [527880]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 527880Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. Epub 2005 Nov 21.Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.
Ref 527880Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. Epub 2005 Nov 21.Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands.

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