| Drug General Information |
| Drug ID |
D08KQM
|
| Former ID |
DNC008423
|
| Drug Name |
LGD-5552
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C28H26FNO3
|
| Canonical SMILES |
CC1=CC=CC(=C1F)C=C2C3=C(C=CC4=C3C(=CC(N4)(C)C)C)C5=C(O2<br />)C=CC(=C5OC)O
|
| InChI |
1S/C28H26FNO3/c1-15-7-6-8-17(26(15)29)13-22-24-18(25-21(33-22)12-11-20(31)27(25)32-5)9-10-19-23(24)16(2)14-28(3,4)30-19/h6-14,30-31H,1-5H3/b22-13-
|
| InChIKey |
ACYYHAZVNHMRMQ-XKZIYDEJSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of androgen receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of glucocorticoid receptor |
Target Info |
Inhibitor |
[1]
|
| Progesterone receptor |
Target Info |
Inhibitor |
[1]
|
| Mineralocorticoid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Oocyte meiosis
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Pathways in cancer
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Prostate cancerhsa04080:Neuroactive ligand-receptor interactionhsa04114:Oocyte meiosis
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Progesterone-mediated oocyte maturationhsa04960:Aldosterone-regulated sodium reabsorption
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NetPath Pathway
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EGFR1 Signaling Pathway
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AndrogenReceptor Signaling Pathway
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FSH Signaling PathwayNetPath_14:IL2 Signaling Pathway
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TCR Signaling Pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Coregulation of Androgen receptor activity
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Regulation of Androgen receptor activity
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Nongenotropic Androgen signaling
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Regulation of nuclear beta catenin signaling and target gene transcription
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FOXA1 transcription factor network
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Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class II
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FOXA2 and FOXA3 transcription factor networks
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Glucocorticoid receptor regulatory network
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AP-1 transcription factor networkanthraxpathway:Cellular roles of Anthrax toxin
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PathWhiz Pathway
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Kidney Function
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Reactome
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Nuclear Receptor transcription pathway
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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-1251985:Nuclear signaling by ERBB4
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WikiPathways
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SIDS Susceptibility Pathways
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Integrated Pancreatic Cancer Pathway
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Prostate Cancer
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Integrated Breast Cancer Pathway
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Nuclear Receptors
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Androgen receptor signaling pathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
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Endoderm Differentiation
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Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
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Adipogenesis
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Circadian Clock
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Nuclear ReceptorsWP34:Ovarian Infertility Genes
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Signaling by ERBB4
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Nuclear ReceptorsWP554:ACE Inhibitor Pathway
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| References |
| REF 1 | Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. Epub 2007 Nov 21.Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. |
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