Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08JEI
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| Former ID |
DNC005824
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| Drug Name |
6-(Naphthalene-2-sulfonyl)-2H-pyridazin-3-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H10N2O3S
|
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| Canonical SMILES |
C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)C3=NNC(=O)C=C3
|
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| InChI |
1S/C14H10N2O3S/c17-13-7-8-14(16-15-13)20(18,19)12-6-5-10-3-1-2-4-11(10)9-12/h1-9H,(H,15,17)
|
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| InChIKey |
HXEYVOPGUKCHBE-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Aldose reductase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Methylglyoxal degradation III | ||||
| Acetone degradation I (to methylglyoxal) | |||||
| KEGG Pathway | Pentose and glucuronate interconversions | ||||
| Fructose and mannose metabolism | |||||
| Galactose metabolism | |||||
| Glycerolipid metabolism | |||||
| Metabolic pathways | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| PathWhiz Pathway | Fructose and Mannose Degradation | ||||
| Pyruvate Metabolism | |||||
| Pterine Biosynthesis | |||||
| Glycerolipid Metabolism | |||||
| Galactose Metabolism | |||||
| WikiPathways | Metapathway biotransformation | ||||
| Polyol Pathway | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| References | |||||
| REF 1 | J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. | ||||
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