| Drug General Information |
| Drug ID |
D08JCU
|
| Former ID |
DNC007934
|
| Drug Name |
(E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H14FNOS
|
| Canonical SMILES |
C1=CC=C(C=C1)S(=O)C2=CN=C(C=C2)C=CC3=CC=C(C=C3)F
|
| InChI |
1S/C19H14FNOS/c20-16-9-6-15(7-10-16)8-11-17-12-13-19(14-21-17)23(22)18-4-2-1-3-5-18/h1-14H/b11-8+
|
| InChIKey |
YFWOOEBYKGJCJO-DHZHZOJOSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Potassium voltage-gated channel subfamily H member 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
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Gap junction
|
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Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
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5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
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PathWhiz Pathway
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Muscle/Heart Contraction
|
|
Reactome
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Voltage gated Potassium channelsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling events
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WikiPathways
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SIDS Susceptibility Pathways
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Hematopoietic Stem Cell Differentiation
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Potassium ChannelsWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2007 May 1;17(9):2643-8. Epub 2007 Feb 2.2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands. |
|---|
