Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08EVM
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| Former ID |
DIB001034
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| Drug Name |
FR-128998
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| Indication | Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] | Terminated | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
S1(=O)(=O)[C@@]2(CC(=O)N(CC1)Cc1cnccc1)[C@H](Cc1ccccc1)<br />CCCC2.Cl
|
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| CAS Number |
CAS 133321-57-0
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| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004313) | ||||
| REF 2 | Effect of FR128998, a novel PAF receptor antagonist, on endotoxin-induced disseminated intravascular coagulation. Eur J Pharmacol. 1994 Jun 13;258(3):239-46. | ||||
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