Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08DTT
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| Former ID |
DIB000559
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| Drug Name |
Androgen receptor modulators
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| Synonyms |
Androgen receptor modulators (osteoporosis); Androgen agonists (osteoporosis), Merck & Co; Androgen receptor modulators (osteoporosis), Merck & Co; SARMs (osteoporosis), Merck & Co
|
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| Indication | Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890] | Investigative | [1] | ||
| Company |
Merck & Co Inc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
[nH]1c(nc2c1cccn2)C[C@@H]1[C@]2(CC[C@@H]3[C@]4(C=CC(=O)<br />N(C4CC[C@H]3[C@@H]2CC1)C)C)C
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| Target and Pathway | |||||
| Target(s) | Androgen receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Oocyte meiosis | ||||
| Pathways in cancer | |||||
| Prostate cancer | |||||
| NetPath Pathway | EGFR1 Signaling Pathway | ||||
| AndrogenReceptor Signaling Pathway | |||||
| FSH Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Coregulation of Androgen receptor activity | |||||
| Regulation of Androgen receptor activity | |||||
| Nongenotropic Androgen signaling | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| FOXA1 transcription factor network | |||||
| Notch-mediated HES/HEY network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Nuclear Receptors | |||||
| Androgen receptor signaling pathway | |||||
| References | |||||
| REF 1 | Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. J Biol Chem. 2010 May 28;285(22):17054-64. | ||||
| REF 2 | The ChEMBL database in 2017. | ||||
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