Drug General Information
Drug ID	D08DCP
Former ID	DNCL002303
Drug Name	BI-847325
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[523412]
Company	Boehringer Ingelheim Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	MEK protein kinase	Target Info	Modulator
	Aurora kinase B	Target Info	Modulator
KEGG Pathway	MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	Oocyte meiosis
	PI3K-Akt signaling pathway
	Vascular smooth muscle contraction
	Dorso-ventral axis formation
	VEGF signaling pathway
	Osteoclast differentiation
	Focal adhesion
	Gap junction
	Signaling pathways regulating pluripotency of stem cells
	Toll-like receptor signaling pathway
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	TNF signaling pathway
	Long-term potentiation
	Neurotrophin signaling pathway
	Cholinergic synapse
	Serotonergic synapse
	Long-term depression
	Regulation of actin cytoskeleton
	Insulin signaling pathway
	GnRH signaling pathway
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Prion diseases
	Alcoholism
	Hepatitis B
	Influenza A
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Colorectal cancer
	Renal cell carcinoma
	Pancreatic cancer
	Endometrial cancer
	Glioma
	Prostate cancer
	Thyroid cancer
	Melanoma
	Bladder cancer
	Chronic myeloid leukemia
	Acute myeloid leukemia
	Non-small cell lung cancer
	Central carbon metabolism in cancer
	Choline metabolism in cancer
Pathway Interaction Database	Aurora B signaling
	Signaling by Aurora kinases
	Aurora C signaling
	FOXM1 transcription factor network
	Aurora A signaling
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
	Insulin Signalling
Reactome	MAPK3 (ERK1) activation
	Uptake and function of anthrax toxins
	RAF activation
	MAP2K and MAPK activation
	Negative feedback regulation of MAPK pathway
	MAP3K8 (TPL2)-dependent MAPK1/3 activationR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
	Mitotic Prometaphase
WikiPathways	Toll-like receptor signaling pathway
	Serotonin Receptor 4/6/7 and NR3C Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Serotonin HTR1 Group and FOS Pathway
	TCR Signaling Pathway
	ErbB Signaling Pathway
	Hypothetical Network for Drug Addiction
	Senescence and Autophagy in Cancer
	EPO Receptor Signaling
	Regulation of Actin Cytoskeleton
	IL-2 Signaling Pathway
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	MAPK Cascade
	MAPK Signaling Pathway
	TGF beta Signaling Pathway
	IL-6 signaling pathway
	Signaling of Hepatocyte Growth Factor Receptor
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Bladder Cancer
	Cardiac Hypertrophic Response
	MAP kinase activation in TLR cascade
	RAF/MAP kinase cascade
	Nanoparticle-mediated activation of receptor signaling
	Structural Pathway of Interleukin 1 (IL-1)
	Genes and (Common) Pathways Underlying Drug Addiction
	Nifedipine Activity
	PDGF Pathway
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Corticotropin-releasing hormone
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	B Cell Receptor Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSLP Signaling Pathway
	IL-9 Signaling Pathway
	Endothelin Pathways
	IL-7 Signaling Pathway
	Leptin signaling pathway
	RANKL/RANK Signaling Pathway
	IL-1 signaling pathway
	Signaling by FGFR
	Integrin-mediated Cell Adhesion
	L1CAM interactions
	MicroRNAs in cardiomyocyte hypertrophy
	Regulation of toll-like receptor signaling pathway
	Osteopontin Signaling
	IL-5 Signaling PathwayWP2757:Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Regulation of Microtubule Cytoskeleton
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	APC/C-mediated degradation of cell cycle proteins
References
Ref 523412	ClinicalTrials.gov (NCT01324830) Monotherapy Dose Finding With BI 847325 in Solid Tumours. U.S. National Institutes of Health.

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