Drug General Information
Drug ID	D08CLN
Former ID	DIB016076
Drug Name	Suritozole
Synonyms	MDL-26479
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Discontinued in Phase 2	[544851]
Company	Hoechst Marion Roussel Inc
Structure		Download 2D MOL 3D MOL
Formula	C10H10FN3S
Canonical SMILES	n1(c(nn(c1=S)C)c1cc(F)ccc1)C
CAS Number	CAS 110623-33-1
PubChem Compound ID	25431
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[533581]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 544851	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001322)
Ref 533581	Chronic postinjury administration of MDL 26,479 (Suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J Neurosurg. 1995 Nov;83(5):878-83.

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