Drug Information

Drug General Information
Drug ID
D08CJK
Former ID
DNC011705
Drug Name
TRYPTAMINE
Drug Type
Small molecular drug
Indication Discovery agent Phase 3 [521730], [538764]
Structure
Download
2D MOL

3D MOL
Formula
C10H12N2
InChI
InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2
InChIKey
APJYDQYYACXCRM-UHFFFAOYSA-N
PubChem Compound ID
1150
PubChem Substance ID
3688, 627609, 841457, 3137852, 7709293, 8144910, 8150070, 8151004, 10529894, 11109978, 11109979, 11109980, 11109984, 11110664, 11336037, 11361276, 11362807, 11365369, 11367931, 11373000, 11374597, 11376093, 11462248, 11484681, 11488689, 11491705, 11492665, 11493847, 11532548, 11537824, 14719299, 14891690, 16964790, 24439500, 24851608, 26612546, 26679319, 26716180, 26737137, 26748861, 26748862, 26753741, 37457994, 47365250, 47440318, 47959807, 48035188, 48185049, 49748640, 49748641
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Inhibitor [526993]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [533464]
Amine oxidase [flavin-containing] A Target Info Inhibitor [526993]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation II
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Inflammatory mediator regulation of TRP channelshsa00260:Glycine, serine and threonine metabolism
Alcoholism
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release Cycle
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compoundsWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP706:SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter Activity
References
Ref 521730ClinicalTrials.gov (NCT00227136) Effect of Oral 5-HTP Intake on Urinary 5-HIAA Excretion. U.S. National Institutes of Health.
Ref 538764(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 125).
Ref 526993Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.
Ref 533464J Med Chem. 1987 Jan;30(1):1-12.Central serotonin receptors as targets for drug research.

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