Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08BYK
|
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| Former ID |
DNC000760
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| Drug Name |
Hypericum
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Phase 4 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C9H12N2O4S
|
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| Canonical SMILES |
CC1(C(N2C(S1)C(C2=O)NC=O)C(=O)O)C
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| InChI |
1S/C9H12N2O4S/c1-9(2)5(8(14)15)11-6(13)4(10-3-12)7(11)16-9/h3-5,7H,1-2H3,(H,10,12)(H,14,15)/t4-,5+,7-/m1/s1
|
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| InChIKey |
MDQGTDMBVJCTBN-JCGDXUMPSA-N
|
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| CAS Number |
CAS 26305-03-3
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [2] | |
| PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | ||||
| WikiPathways | Monoamine Transport | ||||
| NRF2 pathway | |||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00557427) Hypericum vs Fluoxetine for Mild to Moderate Adolescent Depression. U.S. National Institutes of Health. | ||||
| REF 2 | The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.). Mol Psychiatry. 1999 Jul;4(4):333-8. | ||||
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