Drug Information

Drug General Information
Drug ID
D07WRW
Former ID
DIB002017
Drug Name
LADIRUBICIN
Synonyms
FCE-28729; PNU-159548; Ladirubicin < Prop INN >; 3'-(1-Aziridinyl)-3'-deamino-4-demethoxy-4'-O-(methanesulfonyl)daunomycin
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 2 [526474]
Structure
Download
2D MOL

3D MOL
Formula
C29H31NO11S
Canonical SMILES
C[C@@H]1OC(C[C@@H]([C@@H]1OS(=O)(=O)C)N2CC2)O[C@H]3C[C@<br />@](O)(Cc4c(O)c5C(=O)c6ccccc6C(=O)c5c(O)c34)C(=O)C
InChI
1S/C29H31NO11S/c1-13-28(41-42(3,37)38)18(30-8-9-30)10-20(39-13)40-19-12-29(36,14(2)31)11-17-21(19)27(35)23-22(26(17)34)24(32)15-6-4-5-7-16(15)25(23)33/h4-7,13,18-20,28,34-36H,8-12H2,1-3H3/t13-,18-,19-,20?,28+,29-/m0/s1
InChIKey
VMDWTZZCNDEKIO-MPBJIDKLSA-N
PubChem Compound ID
216232
Target and Pathway
Target(s) Human DNA Target Info Binder [527651]
References
Ref 526474Phase I and pharmacokinetic studies of PNU-159548, a novel alkycycline, administered intravenously to patients with advanced solid tumours. Eur J Cancer. 2002 Dec;38(18):2407-15.
Ref 527651The power and potential of doxorubicin-DNA adducts. IUBMB Life. 2005 Feb;57(2):73-81.

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