Drug General Information
Drug ID	D07WDQ
Former ID	DNC011350
Drug Name	GNF-PF-67
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531262]
Structure		Download 2D MOL 3D MOL
Formula	C7H7N5O2
Canonical SMILES	CN1C2=NC(=O)N(C(=O)C2=NC=N1)C
InChI	1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
InChIKey	SLGRAIAQIAUZAQ-UHFFFAOYSA-N
PubChem Compound ID	66541
Target and Pathway
Target(s)	Heat shock protein HSP 90	Target Info	Inhibitor	[531262]
	Heat shock protein HSP90	Target Info	Inhibitor	[531262]
KEGG Pathway	Protein processing in endoplasmic reticulum
	PI3K-Akt signaling pathway
	Antigen processing and presentation
	NOD-like receptor signaling pathway
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Pathways in cancer
	Prostate cancer
NetPath Pathway	IL2 Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class II
	Validated targets of C-MYC transcriptional activation
	Integrin-linked kinase signaling
	LKB1 signaling events
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Class I PI3K signaling events
	IL2 signaling events mediated by PI3K
	Regulation of Androgen receptor activity
	Integrins in angiogenesis
	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
	ErbB receptor signaling network
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	Class I PI3K signaling events mediated by Akt
Reactome	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Regulation of actin dynamics for phagocytic cup formation
	eNOS activation
	Regulation of PLK1 Activity at G2/M Transition
	Attenuation phase
	HSF1-dependent transactivation
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated vascular permeability
	Anchoring of the basal body to the plasma membrane
	Constitutive Signaling by EGFRvIII
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Aryl Hydrocarbon Receptor Pathway
	Binding and Uptake of Ligands by Scavenger Receptors
	Signaling by ERBB2
	Fcgamma receptor (FCGR) dependent phagocytosis
	Influenza Life Cycle
	EBV LMP1 signaling
	Aryl Hydrocarbon Receptor
	Corticotropin-releasing hormone
	TNF alpha Signaling Pathway
	Arylhydrocarbon receptor (AhR) signaling pathway
	Signaling by EGFR
	Semaphorin interactions
	Mitotic G2-G2/M phases
	Metabolism of nitric oxide
	NOD pathway
References
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 531262	Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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