Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07VZV
|
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| Former ID |
DIB004109
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| Drug Name |
N-0861
|
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| Synonyms |
WRC-0006; WRC-0007
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| Drug Type |
Small molecular drug
|
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| Indication | Cardiac disease [ICD10:I00-I99] | Discontinued in Phase 3 | [1] | ||
| Company |
Aderis Pharmaceuticals Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C13H17N5
|
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| Canonical SMILES |
c12ncn(c1ncnc2N[C@H]1[C@H]2C[C@@H](C1)CC2)C
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Adenosine A1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | |||||
| Sphingolipid signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Morphine addiction | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| RANKL Signaling Pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Adenosine P1 receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003285) | ||||
| REF 2 | N-0861 selectively antagonizes adenosine A1 receptors in vivo. Eur J Pharmacol. 1992 May 27;216(1):9-16. | ||||
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