Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07SZJ
|
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| Former ID |
DIB014734
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| Drug Name |
A-75169
|
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| Synonyms |
A-74324; A-74325
|
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| Indication | Glaucoma [ICD9: 365; ICD10:H40-H42] | Terminated | [1] | ||
| Company |
Abbott Laboratories
|
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| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c12c(cc(cc2)O)CCCC1CN(CCc1ccccc1)C
|
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| CAS Number |
CAS 125067-40-5
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| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003469) | ||||
| REF 2 | A-75169 HCI: Pharmacological profile and ocular pharmacology studies of a new alpha-2 antagonist. Drug Development Research Volume 28, Issue 1, pages 56-64, January 1993. | ||||
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