Drug General Information
Drug ID
D07SRW
Former ID
DNC007519
Drug Name
His-DPhe-Arg-Trp
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528799]
Structure
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2D MOL

3D MOL

Formula
C32H40N10O5
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC2=CNC3=CC=<br />CC=C32)C(=O)O)NC(=O)C(CC4=CN=CN4)N
InChI
1S/C32H40N10O5/c33-23(15-21-17-36-18-39-21)28(43)41-26(13-19-7-2-1-3-8-19)30(45)40-25(11-6-12-37-32(34)35)29(44)42-27(31(46)47)14-20-16-38-24-10-5-4-9-22(20)24/h1-5,7-10,16-18,23,25-27,38H,6,11-15,33H2,(H,36,39)(H,40,45)(H,41,43)(H,42,44)(H,46,47)(H4,34,35,37)/t23-,25-,26-,27-/m0/s1
InChIKey
CAYNQHPLZNPBIO-MNUOIFNESA-N
PubChem Compound ID
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Inhibitor [528799]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528799Bioorg Med Chem Lett. 2007 Jun 15;17(12):3310-3. Epub 2007 Apr 6.Squalene-derived flexible linkers for bioactive peptides.
Ref 528799Bioorg Med Chem Lett. 2007 Jun 15;17(12):3310-3. Epub 2007 Apr 6.Squalene-derived flexible linkers for bioactive peptides.

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