Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07QBJ
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| Former ID |
DIB006449
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| Drug Name |
HJP-272
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| Synonyms |
HJP-272; Endothelin type A receptor antagonist (premature birth, inflammation); ETA antagonist (premature birth, lung inflammation), St Johns University; Endothelin type A receptor antagonist (premature birth, inflammation), St Johns University
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| Indication | Premature labour [ICD9: 644, 765; ICD10:O60.1, P07.3] | Investigative | [1] | ||
| Company |
St Johns University
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
n1(c(c(c(=O)c2cc(ccc12)O)Cc1cc(ccc1)C(=O)O)C(=O)O)Cc1c(<br />cc2OCOc2c1)CC
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| Target and Pathway | |||||
| Target(s) | Endothelin-1 receptor | Target Info | Antagonist | [1] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Renin secretion | |||||
| Pathways in cancer | |||||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Endothelin signaling pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| EGFR-dependent Endothelin signaling events | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 219). | ||||
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