Drug General Information
Drug ID
D07PZQ
Former ID
DIB020239
Drug Name
L-serine-O-phosphate
Synonyms
LSOP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538888]
Structure
Download
2D MOL

3D MOL

Formula
C3H8NO6P
InChI
InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKey
BZQFBWGGLXLEPQ-REOHCLBHSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mGlu6 receptor Target Info Agonist [534382]
Metabotropic glutamate receptor 4 Target Info Agonist [533900]
Metabotropic glutamate receptor 7 Target Info Agonist [525945]
Metabotropic glutamate receptor 8 Target Info Agonist [525476]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transductionhsa04080:Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
GPCRs, Other
References
Ref 538888(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1411).
Ref 525476Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10.
Ref 525945Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
Ref 533900Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 1993 Sep;4(9):1099-101.
Ref 534382Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.