Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07PLK
|
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| Former ID |
DIB016402
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| Drug Name |
WIN-64821
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| Synonyms |
Q-20547A
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| Drug Type |
Small molecular drug
|
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| Indication | Asthma [ICD10:J45] | Terminated | [1] | ||
| Company |
Sterling Winthrop Products Inc
|
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| Structure |
|
Download2D MOL |
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| Formula |
C40H36N6O4
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| Canonical SMILES |
[C@]12([C@]34[C@@H](N5[C@@H](C4)C(=O)N[C@H](C5=O)Cc4ccc<br />cc4)Nc4c3cccc4)[C@@H](N3[C@@H](C2)C(=O)N[C@H](C3=O)Cc2c<br />cccc2)Nc2c1cccc2
|
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| CAS Number |
CAS 150881-27-9
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005879) | ||||
| REF 2 | WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. II. Biological activity. J Antibiot (Tokyo). 1994 Apr;47(4):399-410. | ||||
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