Drug Information

Drug General Information
Drug ID
D07OEY
Former ID
DIB010533
Drug Name
ZK-118182
Drug Type
Small molecular drug
Indication Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Terminated [539190], [545456]
Company
Bayer Schering Pharma AG
Structure
Download
2D MOL

3D MOL
Formula
C21H33ClO5
InChI
InChI=1S/C21H33ClO5/c1-14-6-2-3-7-15(14)19(23)10-9-17-16(18(22)12-20(17)24)8-4-5-11-27-13-21(25)26/h4-5,9-10,14-20,23-24H,2-3,6-8,11-13H2,1H3,(H,25,26)/b5-4-,10-9+/t14?,15?,16-,17-,18-,19-,20-/m1/s1
InChIKey
JPMWVHYATGJOOX-OSIODEBVSA-N
CAS Number
CAS 120962-76-7
PubChem Compound ID
5311208
PubChem Substance ID
7979700, 39340916, 51730447, 57359389, 114155547, 135651361
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Modulator [525716]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539190(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1890).
Ref 545456Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003331)
Ref 525716Characterization of prostanoid receptors mediating inhibition of histamine release from anti-IgE-activated rat peritoneal mast cells. Br J Pharmacol. 2000 Feb;129(3):589-97.

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