| Drug General Information |
| Drug ID |
D07MXA
|
| Former ID |
DNC000376
|
| Drug Name |
C75
|
| Drug Type |
Small molecular drug
|
| Indication |
Obesity [ICD9: 278; ICD10:E66]
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H22O4
|
| Canonical SMILES |
CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O
|
| InChI |
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
|
| InChIKey |
VCWLZDVWHQVAJU-NEPJUHHUSA-N
|
| CAS Number |
CAS 191282-48-1
|
| PubChem Compound ID |
|
| PubChem Substance ID |
14847821, 24695827, 26740885, 26758695, 45628459, 53837775, 57373648, 77879576, 92711145, 103610284, 104107766, 126631158, 134339819, 152100035, 163122639, 163393237, 163688148, 164765421, 165225950, 198953192, 204378101, 206245597, 229062152, 252457542
|
| Target and Pathway |
| Target(s) |
Fatty acid synthase |
Target Info |
Inhibitor |
[1]
|
|---|
| Carnitine O-palmitoyltransferase I |
Target Info |
Activator |
[1]
|
|
BioCyc Pathway
|
Fatty acid biosynthesis initiation
|
|
Fatty acid elongation -- saturated
|
|
Palmitate biosynthesis
|
|
KEGG Pathway
|
Fatty acid biosynthesis
|
|
Metabolic pathways
|
|
Fatty acid metabolism
|
|
AMPK signaling pathway
|
|
Insulin signaling pathwayhsa00071:Fatty acid degradation
|
|
PPAR signaling pathway
|
|
Adipocytokine signaling pathway
|
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Glucagon signaling pathway
|
|
Pathway Interaction Database
|
p73 transcription factor network
|
|
Validated transcriptional targets of deltaNp63 isoforms
|
|
PathWhiz Pathway
|
Fatty Acid BiosynthesisPW000023:Fatty acid Metabolism
|
|
Reactome
|
ChREBP activates metabolic gene expression
|
|
Activation of gene expression by SREBF (SREBP)
|
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Fatty Acyl-CoA BiosynthesisR-HSA-1368082:RORA activates gene expression
|
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PPARA activates gene expression
|
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Import of palmitoyl-CoA into the mitochondrial matrix
|
|
WikiPathways
|
Fatty Acid Biosynthesis
|
|
Nuclear Receptors Meta-Pathway
|
|
Liver X Receptor Pathway
|
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Activation of Gene Expression by SREBP (SREBF)
|
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SREBF and miR33 in cholesterol and lipid homeostasis
|
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SREBP signalling
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Metabolism of water-soluble vitamins and cofactors
|
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Integration of energy metabolism
|
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Fatty acid, triacylglycerol, and ketone body metabolism
|
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AMPK SignalingWP706:SIDS Susceptibility Pathways
|
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Mitochondrial LC-Fatty Acid Beta-Oxidation
|
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PPAR Alpha Pathway
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Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Circadian Clock
|
|
Fatty Acid Beta Oxidation
|
|
AMPK Signaling
|
| References |
| REF 1 | C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. Epub 2002 Jun 11. |
|---|
