Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07MVE
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| Former ID |
DIB011519
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| Drug Name |
PD-151832
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| Synonyms |
PD-142505 (racemate); (-)-(R)-(Z)-3-[3-(3-Methoxyphenyl)-2-propynyloxyimino]-1-azabicyclo[2.2.1]heptane
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| Drug Type |
Small molecular drug
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Discontinued in Phase 1/2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H18N2O2
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| Canonical SMILES |
COc1cccc(c1)C#CCO\\N=C\\2/CN3CCC2C3
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| InChI |
1S/C16H18N2O2/c1-19-15-6-2-4-13(10-15)5-3-9-20-17-16-12-18-8-7-14(16)11-18/h2,4,6,10,14H,7-9,11-12H2,1H3/b17-16+
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| InChIKey |
FXBXWJPMXQHOGD-WUKNDPDISA-N
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| CAS Number |
CAS 149929-38-4
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M1 | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PI3K-Akt signaling pathway | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006926) | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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