Drug Information

Drug General Information
Drug ID
D07MON
Former ID
DNC003727
Drug Name
ONAPRISTONE
Drug Type
Small molecular drug
Indication Contraception [ICD10:Z30] Phase 1/2 [524622], [539909]
Structure
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2D MOL

3D MOL
Formula
C29H39NO3
InChI
InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
InChIKey
IEXUMDBQLIVNHZ-YOUGDJEHSA-N
PubChem Compound ID
5311505
PubChem Substance ID
7980914, 11056548, 12013541, 14857593, 14881951, 39341170, 49965771, 53787493, 76459509, 114156235, 124490311, 135016552, 135650760, 136946112, 140852942, 160845660, 162179251, 164786732, 179151473, 198987362, 226399859, 241167836, 244262591, 252355542, 252818373
Target and Pathway
Target(s) Progesterone receptor Target Info Modulator
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 524622ClinicalTrials.gov (NCT02049190) Phase 1-2 Study of Onapristone in Patients With Advanced Castration-resistant Prostate Cancer. U.S. National Institutes of Health.
Ref 539909(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2882).

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