| Drug General Information |
| Drug ID |
D07MEH
|
| Former ID |
DAP001495
|
| Drug Name |
Meglitinides
|
| Drug Type |
Small molecular drug
|
| Indication |
Hyperglycaemia in type 2 diabetes [ICD9: 250, 790.29; ICD10:E11, R73.9]
|
Approved |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H20Cl2N2O3
|
| Canonical SMILES |
CCN1CCCC1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
|
| InChI |
1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
|
| InChIKey |
WAOQONBSWFLFPE-VIFPVBQESA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
7980481, 10047782, 11114224, 12013470, 14827538, 26719717, 26752250, 36077621, 46386981, 47515551, 47810996, 48185204, 49681662, 50104962, 53787975, 57352765, 77953791, 85788759, 90340860, 91746408, 92308273, 92308736, 103167993, 103918664, 111634979, 124658776, 124800057, 124887054, 129553949, 134338685, 134340417, 135014074, 135650880, 135698402, 137237422, 142971008, 144204512, 152106370, 160821969, 162023238, 163091727, 163383825, 170466218, 170485724, 172080125, 172860716, 176484026, 178100336, 179151282, 198978423
|
| Target and Pathway |
| Target(s) |
Insulin receptor |
Target Info |
Stimulator |
[1]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
PI3K-Akt signaling pathway
|
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AMPK signaling pathway
|
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Adherens junction
|
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Insulin signaling pathway
|
|
Ovarian steroidogenesis
|
|
Type II diabetes mellitus
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
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Aldosterone-regulated sodium reabsorption
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
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PI3 kinase pathway
|
|
Pathway Interaction Database
|
Insulin Pathway
|
|
Signaling events mediated by PTP1B
|
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Signaling events mediated by TCPTP
|
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Insulin-mediated glucose transport
|
|
PathWhiz Pathway
|
Insulin Signalling
|
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Leucine Stimulation on Insulin Signaling
|
|
Reactome
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IRS activation
|
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Signal attenuation
|
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Insulin receptor signalling cascade
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Insulin receptor recycling
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WikiPathways
|
DNA Damage Response (only ATM dependent)
|
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Insulin Signaling
|
|
Nanoparticle triggered autophagic cell death
|
|
AGE/RAGE pathway
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Signaling by Insulin receptor
|
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Folate Metabolism
|
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Type II diabetes mellitus
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient Network
|
|
AMPK Signaling
|
| References |
| REF 1 | New drugs for type 2 diabetes mellitus: what is their place in therapy? Drugs. 2008;68(15):2131-62. |
|---|
