Drug Information

Drug General Information
Drug ID
D07LCY
Former ID
DIB006342
Drug Name
RVSVIN HIV-1 gag vaccine
Synonyms
RVSVIN HIV-1 gag vaccine, Profectus Biosciences; RVSV vector-based HIV-1 vaccine, Profectus BioSciences; Recombinant VSV vector-based HIV-1 vaccine, Profectus BioSciences; Recombinant vesicular stomatitis virus vector-based HIV-1 vaccine, Profectus BioSciences
Drug Type
Vaccine
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1 [549955]
Company
Wyeth Pharmaceuticals
Target and Pathway
Target(s) HIV GAG protein Target Info [531652]
Reactome Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
2-LTR circle formation
Binding and entry of HIV virion
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
Integration of viral DNA into host genomic DNA
Autointegration results in viral DNA circles
APOBEC3G mediated resistance to HIV-1 infection
Vpr-mediated nuclear import of PICs
WikiPathways Host Interactions of HIV factors
HIV Life Cycle
References
Ref 549955Attenuation of Recombinant Vesicular Stomatitis Virus-Human Immunodeficiency Virus Type 1 Vaccine Vectors by Gene Translocations and G Gene Truncation Reduces Neurovirulence and Enhances Immunogenicity in Mice. J. Virol. January 2008 vol. 82 no. 1 207-219.
Ref 531652Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections. J Infect Dis. 2011 Nov;204 Suppl 3:S1075-81.

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