Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07KYU
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| Former ID |
DNC000293
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| Drug Name |
Benactyzine
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| Drug Type |
Small molecular drug
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| Indication | Depression [ICD9: 311; ICD10:F30-F39] | Withdrawn from market | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C20H25NO3
|
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| Canonical SMILES |
CCN(CC)CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)O
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| InChI |
1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3
|
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| InChIKey |
IVQOFBKHQCTVQV-UHFFFAOYSA-N
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| CAS Number |
CAS 302-40-9
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5589361, 8156673, 10517764, 15323332, 29215374, 29215375, 29227934, 48415604, 49882418, 51091823, 57325585, 76110435, 88826491, 95651880, 103267925, 104033594, 104320212, 115997952, 124892194, 126688208, 128227073, 134223988, 134339757, 134973255, 137131399, 144205218, 162224672, 169174904, 170466568, 179225185, 198987026, 223667229, 226432918, 241059525, 249950785
|
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| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M5 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Benactyzine as an aid in treatment of anxiety states; preliminary report. Br Med J. 1957 Feb 9;1(5014):306-10. | ||||
| REF 2 | The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85. | ||||
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