Drug General Information
Drug ID
D07JDU
Former ID
DNC010166
Drug Name
SB-706375
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539372]
Structure
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2D MOL

3D MOL

Formula
C20H22BrF3N2O5S
InChI
InChI=1S/C20H22BrF3N2O5S/c1-26-7-6-13(11-26)31-16-8-12(4-5-14(16)20(22,23)24)25-32(27,28)19-10-18(30-3)17(29-2)9-15(19)21/h4-5,8-10,13,25H,6-7,11H2,1-3H3/t13-/m1/s1
InChIKey
BPOWQJYAMDEAFF-CYBMUJFWSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Urotensin II receptor Target Info Inhibitor [530610]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539372(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2165).
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.

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