Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07JCI
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| Former ID |
DIB012035
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| Drug Name |
MCHR1 antagonists
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| Synonyms |
Melanin-concentrating hormone receptor 1 antagonists (obesity); Melanin-concentrating hormone receptor 1 antagonists (obesity), AstraZeneca
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| Indication | Obesity [ICD9: 278; ICD10:E66] | Investigative | [1] | ||
| Company |
AstraZeneca plc
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
C(=O)(COc1cc(ccc1)Cl)NC1CCN(CC1)Cc1cn(cc1)c1ccc(cc1)OC(<br />F)(F)F
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| Target and Pathway | |||||
| Target(s) | Melanin-concentrating hormone receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment? Bioorg Med Chem Lett. 2012 Oct 1;22(19):6039-47 | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 280). | ||||
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