Drug Information

Drug General Information
Drug ID
D07IIX
Former ID
DIB011752
Drug Name
AMELTOLIDE
Synonyms
BAN; ADD-75073; Ameltolide < Prop INN; LY-201116; 4-Amino-N-(2,6-dimethylphenyl)benzamide
Drug Type
Small molecular drug
Indication Epileptic seizures [ICD9: 345.9, 780.3; ICD10:G40, P90, R56] Discontinued in Phase 1 [546417]
Structure
Download
2D MOL

3D MOL
Formula
C15H16N2O
Canonical SMILES
Cc1cccc(C)c1NC(=O)c2ccc(N)cc2
InChI
1S/C15H16N2O/c1-10-4-3-5-11(2)14(10)17-15(18)12-6-8-13(16)9-7-12/h3-9H,16H2,1-2H3,(H,17,18)
InChIKey
HZIWGOAXOBPQGY-UHFFFAOYSA-N
CAS Number
CAS 787-93-9
PubChem Compound ID
13086
Target and Pathway
Target(s) Sodium channel Target Info Modulator [530733], [551871]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 546417Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008003)
Ref 530733Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant. J Med Chem. 1991 Apr;34(4):1253-7.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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