Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07HRU
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| Former ID |
DCL000355
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| Drug Name |
KRN633
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| Synonyms |
KRN-633; VEGF Receptor Tyrosine Kinase Inhibitor III, KRN633; KRN633, KRN-633, KRN 633; N-(2-Chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-N′-propylurea
|
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Company |
Kirin
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| Structure |
|
Download2D MOL |
|||
| Formula |
C20H21ClN4O4
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| InChI |
InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
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| InChIKey |
VPBYZLCHOKSGRX-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
14720360, 14806768, 23984867, 26759727, 44692624, 51897954, 53800456, 103567372, 104253211, 124757337, 125164141, 134339007, 136348252, 136367547, 142749305, 152258380, 160647217, 160854732, 162011869, 162037666, 162202674, 163679255, 163687135, 163907982, 172919154, 174006598, 174528673, 175426544, 178102678, 180372408, 185974477, 208264677, 223395524, 223705286, 223904226, 227478640, 243575836, 249814488, 251910663, 252215651
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | Inhibitor | [536474] | |
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
| Ref 541306 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6057). | ||||
| Ref 547568 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017407) | ||||
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