Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07HQZ
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| Former ID |
DIB018321
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| Drug Name |
[3H]LSD
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| Synonyms |
[3H]N,N-diethyllysergamide; [3H]lysergic acid diethylamide; [3H]lysergide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [539390] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C20H25N3O
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| InChI |
InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1/i3T3
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| InChIKey |
VAYOSLLFUXYJDT-QZGBZKRISA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 7 receptor | Target Info | Agonist | [534474] | |
| 5-hydroxytryptamine 2B receptor | Target Info | Agonist | [526621] | ||
| 5-hydroxytryptamine 6 receptor | Target Info | Agonist | [525492] | ||
| 5-hydroxytryptamine 2C receptor | Target Info | Agonist | [543963] | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapsehsa04020:Calcium signaling pathway | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling | |||||
| GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| References | |||||
| Ref 525492 | Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. | ||||
| Ref 526621 | Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 2003 May 30;73(2):193-207. | ||||
| Ref 534474 | Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants. FEBS Lett. 1997 Aug 25;413(3):489-94. | ||||
| Ref 543963 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 8). | ||||
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