Drug General Information
Drug ID	D07FTI
Former ID	DIB021255
Drug Name	zinc pyrithione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539674]
Structure		Download 2D MOL
Formula	C10H8N2O2S2Zn
InChI	InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
InChIKey	OTPSWLRZXRHDNX-UHFFFAOYSA-L
PubChem Compound ID	415267
PubChem Substance ID	8137040, 77075702, 210279739, 210282062
Target and Pathway
Target(s)	Kv7.5	Target Info	Activator	[528790]
	Potassium voltage-gated channel subfamily KQT member 4	Target Info	Activator	[528790]
	Potassium voltage-gated channel subfamily KQT member 1	Target Info	Activator	[528790]
	Potassium voltage-gated channel subfamily KQT member 2	Target Info	Activator	[528790]
KEGG Pathway	Cholinergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
	Cholinergic synapse
	Gastric acid secretion
	Pancreatic secretion
	Protein digestion and absorption
	Vibrio cholerae infectionhsa04725:Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channels
	Interaction between L1 and Ankyrins
WikiPathways	Potassium ChannelsWP706:SIDS Susceptibility Pathways
	Potassium Channels
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	TarBasePathwayWP2669:Potassium Channels
	L1CAM interactions
References
Ref 539674	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2597).
Ref 528790	Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. Epub 2007 Apr 15.

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