| Drug General Information |
| Drug ID |
D07FJO
|
| Former ID |
DNC004369
|
| Drug Name |
Pipendoxifene
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C29H32N2O3
|
| Canonical SMILES |
CC1=C(N(C2=C1C=C(C=C2)O)CC3=CC=C(C=C3)OCCN4CCCCC4)C5=CC<br />=C(C=C5)O
|
| InChI |
1S/C29H32N2O3/c1-21-27-19-25(33)11-14-28(27)31(29(21)23-7-9-24(32)10-8-23)20-22-5-12-26(13-6-22)34-18-17-30-15-3-2-4-16-30/h5-14,19,32-33H,2-4,15-18,20H2,1H3
|
| InChIKey |
JICOGKJOQXTAIP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Estrogen receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Estrogen receptor beta |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Estrogen signaling pathway
|
|
Prolactin signaling pathway
|
|
Thyroid hormone signaling pathway
|
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Endocrine and other factor-regulated calcium reabsorption
|
|
Proteoglycans in cancerhsa04915:Estrogen signaling pathway
|
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NetPath Pathway
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FSH Signaling Pathway
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EGFR1 Signaling Pathway
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RANKL Signaling Pathway
|
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Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
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Signaling events mediated by HDAC Class II
|
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Plasma membrane estrogen receptor signaling
|
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LKB1 signaling events
|
|
Regulation of Telomerase
|
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ATF-2 transcription factor network
|
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AP-1 transcription factor network
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FOXM1 transcription factor network
|
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Validated nuclear estrogen receptor alpha network
|
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Signaling mediated by p38-alpha and p38-beta
|
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FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
|
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Validated nuclear estrogen receptor beta network
|
|
Reactome
|
Nuclear signaling by ERBB4
|
|
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
|
|
WikiPathways
|
Estrogen signaling pathway
|
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Nuclear Receptors Meta-Pathway
|
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Estrogen Receptor Pathway
|
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Signaling by ERBB4
|
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JAK/STAT
|
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Integrated Pancreatic Cancer Pathway
|
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Leptin signaling pathway
|
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miR-targeted genes in muscle cell - TarBase
|
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Integrated Breast Cancer Pathway
|
|
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
|
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Ovarian Infertility Genes
|
|
Nuclear Receptors
|
| References |
| REF 1 | J Med Chem. 2001 May 24;44(11):1654-7.Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. |
|---|
